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In clinical and cosmetic literature, this distinction matters because a topical serum, wound gel, liposomal formula, and injectable preparation may have very different safety and absorption profiles

3-PH can obtain an amino group from glutamate and form 3-phosphoserine (3-PS) through phosphoserine transaminase (PSAT) followed by dephosphorylation through serine phosphatase (PSPH) to finally produce serine (Figure 1)